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Is the combination of IP6 with inositol more powerful that IP6 alone?

The simple answer is yes! Dr. Shamsuddin has proven that the combination exerts much greater effect than IP6 alone. This potentiation has been demonstrated in animal models for breast cancer, lung cancer and colon cancer. For example, in one study (Shamsuddin A., Ulah A., Chakravarthy A: Inositol and inositol hexaphosphate suppresses cell proliferation and tumor formation in CD-1 mice. Carcinogenesis 10:1461-1463. 1989) mice were given a compound (DMH) to induce cancer formation. Of these, one group was additionally treated with Inositol & Cal Mag IP6. The results indicate that the mice treated with IP6 alone or inositol alone have lower occurrences of tumors per animal. This benefit was greatly enhanced when Inositol & Cal Mag IP6 were given in combination. The table below clearly illustrates the superiority of the combination.

The Effect of IP6, inositol and the combination of Inositol & Cal Mag IP6 on
intestinal tumors in mice
  Combination
Tumor Prevalence*
Tumor Frequency**
DMH 63% 116 %
DMH + IP-6 47% 62 %
DMH + Inositol 30% 45 %
DMH + Inositol & Cal Mag IP6 25% 25 %
Control 0% 0 %
* Percent of mice with tumors
** Percent of tumors per mouse
The Anti-Cancer Effects of IP6

Based on extensive experimental studies in animals and cell cultures, the combination of Inositol & Cal Mag IP6 exerts anticancer effects against virtually all types of cancers including cancers of the breast, prostate, lung, skin and brain as well as lymphomas and leukemia. The table below lists some of the cancer cells that IP6 has shown activity against.

  Tissue of Organ Type
  Cell Line
Brain tumor
SR.B10A
Breast tumor
MCF-7, MDA-MB-321 & -435
Colon carcinoma
HT-29
Fibroblast (immortalized)
BALBc-3T3
Leukemia
K-562, HL-60
Liver carcinoma
Hep G2
Lung carcinoma
HTB-119, RTE
Prostate carcinoma
PC-3
Skeletal muscle sarcoma
RD
Skin
JB6
To learn more about the ability of IP6 to assist tumor regression click here.
Why is IP6 combined with inositol?

The remarkable combination of IP6 with inositol was originally discovered by Dr Shamsuddin M.D., Ph.D., from the University of Maryland, USA. When combined with IP6, inositol dramatically increases the anticancer and immune enhancing effects of IP6. Dr Shamsuddin discovered that when properly combined with inositol, IP6 forms two molecules of IP3 in the body. Inositol, the backbone structure of IP6, has six carbon atoms that are capable of binding phosphate molecules; when all six carbons are occupied by six phosphate groups IP6 is formed. When only three of the carbon groups are bound by phosphate it is called IP3. This chemistry is important because although IP6 is gaining all the attention, it is really IP3 that is doing all the work. IP3 plays an important role inside the cells of our bodies. It basically functions as an on/off switch for human cancers according to experimental studies in cell cultures (in vitro studies). When IP3 levels are low (as in cancer cells), the cells replicate out of control. That basically is what occurs in cancer. When cancer cells are bathed in IP3, they literally turn themselves off. This action reflects the central role that IP3 plays in controlling key cell functions, including replication and the communication between cells. Dr. Shamsuddin has discovered the correct ratio of Inositol & Cal Mag IP6 to ensure the formation of IP3 within the body.

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